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Vector-borne diseases impose enormous health and economic burdens and additional methods to control vector populations are clearly needed. The Sterile Insect Technique SIT has been successful against agricultural pests, but is not in large-scale use for suppressing or eliminating mosquito populations. Genetic RIDL technology Release of Insects carrying a Dominant Lethal is a proposed modification that involves releasing insects that are homozygous for a repressible dominant lethal genetic construct rather than being sterilized by irradiation, and could potentially overcome some technical difficulties with the conventional SIT technology.
Using the arboviral disease dengue as an example, we combine vector population dynamics and epidemiological models to explore the effect of a program of RIDL releases on disease transmission.
Date listed: 13/6/ ALPHEY. The Funeral Service for Mr Rexon Bruce Alphey, will be held in the Chapel of Repose Altona Memorial Park on Monday 17th.
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Alphey Loves Letters is a children’s book written for year olds and for all children at heart! In this adventure we spend a day with Alphey, a young boy who loves to read every word he sees, from the labels on his clothing to the writing on his toothpaste tube. Read more Read less. Shop now.
Author: Luke Alphey. Date: Feb. From: Nature Biotechnology(Vol. 34, Issue 2). Publisher: Nature Publishing Group. Document Type: Report. Length: 1,
Protocol DOI: Metazoans from Drosophila to humans have multiple genes encoding catalytic subunits of. Metazoans from Drosophila to humans have multiple genes encoding catalytic subunits of PP1 PP1c , which are involved in a wide range of biological processes. Studies in the fruit fly Drosophila melanogaster have revealed some of the essential functions of the PP1c genes.
However, the PP1c isoforms have pleiotropic and overlapping functions, making it difficult to characterize their many biological roles and identify their specific in vivo substrates. The existence of isoform-specific PP1 regulatory subunits might also help to explain the unique roles of different PP1 catalytic subunits.
Rexon Bruce Alphey
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Date listed: 13/6/ ALPHEY. — Bruce. – Loving and loved brother of Noreen, Shirley (dec), Allan (dec). Great brother-in-law to Ern, Lorrie.
Aedes mosquitoes include important vector species such as Aedes aegypti , the major vector of dengue. Genetic control methods are being developed for several of these species, stimulated by an urgent need owing to the poor effectiveness of current methods combined with an increase in chemical pesticide resistance. In this review we discuss the various genetic strategies that have been proposed, their present status, and future prospects.
We focus particularly on those methods that are already being tested in the field, including RIDL and Wolbachia -based approaches. Aedes mosquitoes transmit a range of pathogens that cause substantial human morbidity, mortality, and suffering. Dengue, the most important mosquito-borne viral disease with 50— million infections per year worldwide, 1 , 2 is transmitted primarily by Ae.
Will GM Insects Help Stop Disease?
Invasive species remain one of the greatest threats to global biodiversity. Their control would be enhanced through the development of more effective and sustainable pest management strategies. Recently, a novel form of genetic pest management GPM has been developed in which the mating behaviour of insect pests is exploited to introduce genetically engineered DNA sequences into wild conspecific populations.
Although currently being developed for use against economically important insect pests, these technologies would be highly appropriate for application against invasive species that threaten biodiversity. Here we review the current state of this rapidly progressing field and, using an established set of eradication criteria, discuss the characteristics which make GPM technologies suitable for application against invasive pests.
Current methods for their control are in many cases inadequate to prevent continuing biodiversity loss Genovesi ; Thresher ; Bax and Thresher
Series: Introduction to Biotechniques; Paperback: pages; Publisher: Garland Science; 1 edition (June 30, ); Language: English; ISBN
Insect muscle actin promoter. Patent number: Abstract: Provided is a gene expression system, suitable for expression in an insect, comprising an insect muscle actin promoter operably linked to a marker gene, which overcomes or ameliorates one or more of: cost of rearing; amount of handling; errors in identification due to human error or loss of marker by the insect; and health concerns related to the effects of marker powders on workers in mass rearing facilities.
Type: Grant. Filed: June 23, Date of Patent: October 1, Assignee: Oxitec Limited. Publication number: Abstract: A polynucleotide expression system is provided that is capable of alternative splicing of RNA transcripts of a polynucleotide sequence to be expressed in an organism. Type: Application. Filed: May 1, Publication date: September 6, Applicant: Oxitec Limited.
DE69118204T2 – Bekämpfung von parasitischen nematoden – Google Patents
The successful candidate will lead experimental work on a new BBSRC-funded project to explore the possibility of developing stress-tolerant honey bees, in particular bees less affected by exposure to viral pathogens. The post-holder will report to the senior postdoc on the grant and to Luke Alphey, the Head of Arthropod Genetics and Principal Investigator on the grant. Grant funding is for 36 months. This job description is only an outline of the tasks, responsibilities and outcomes required of the role.
The job description and personal specification may be reviewed on an ongoing basis in accordance with the changing needs of The Pirbright Institute.
Date of creation. UTC ([email protected]). Date of publication Dean D. Thomas, Christl A. Donnelly, Roger J. Wood, Luke S. Alphey.
The present invention relates to breeding strategies for reducing the frequency of, or eliminating, genetic traits, such as pesticide resistance, in a target population. Ways of controlling pests, and especially those which attack important harvests or which are capable of spreading disease, are continually being sought. With each new strategy that is found, for eliminating or neutralising a pest, comes the concern that the pest in question will develop resistance, or become immune, to the strategy.
For example, the Cry1Ac protein from Bacillus thuringiensis can successfully be expressed in many important crops, and is effective as a pesticide, both when used as a spray or when expressed by the plants themselves. However, instances of resistance to Bt toxin have already been noticed amongst the diamondback moth population, for example. As resistance spreads, alternative strategies for controlling pest populations will have to be found. Resistance genes generally confer a level of selective disadvantage.
BRIEF DESCRIPTION OF THE DRAWINGS
Genetic Biocontrol for Invasive Species. John L. Teem, J. Alphey, S.
Record information. Birth, date/date/ city New South Wales Australia. Marriage, dd/mm/year city New South Wales Australia.
Estimation of Aedes aegypti Diptera: Culicidae population size and adult male survival in an urban area in Panama. Traditional mosquito control strategies rely heavily on the use of chemical insecticides. However, concerns about the efficiency of traditional control methods, environmental impact and emerging pesticide resistance have highlighted the necessity for developing innovative tools for mosquito control.
In this report we present the results of a mark-release-recapture study aimed at: i establishing the survival in the field of laboratory-reared, wild-type male Aedes aegypti and b estimating the size of the local adult Ae. The study took place in Panama, a country where recent increases in the incidence and severity of dengue cases have prompted health authorities to evaluate alternative strategies for vector control. Results suggest a life expectancy of 2.
The practical implications of these results are discussed. Key words: Aedes aegypti; daily survival; male mosquito; mark-release-recapture; Panama; population estimation. The disease is caused by infection with one of four serotypes of the dengue virus DENV and is mainly transmitted by the mosquito Aedes aegypti, a species of African origin which is highly anthropophilic and mostly active during daylight hours Christophers First introduced to the Americas during colonial times, Ae.
Unfortunately, countries that did not achieve eradication during this period served as sources for re-infestation and during the following decades Ae. Currently, Ae.